The fallout from Vioxx.

Recent Fukushima nuclear detonation, Chernobyl nuclear fallout, three mile island nuclear accident and atomic bomb explosion – rethinking the effects of nuclear radiations over human health

Background: The earlier Atomic Bomb explosion in Hiroshima and Nagasaki, and three worth mentioning nuclear accidents - detonation at Fukushima Daiichi nuclear plant, Chernobyl nuclear fallout and an accident at Three Mile Island nuclear power plant have made us more worried about the secure exploitation of nuclear energy. The central focus of this paper is to review radiation-mediated health e...

Soil as a Source Contributor in Mineral Dust Fallout at Urban Industrial Residential Area

The components and quantities of atmospheric dusts fallout has been reported to be the pollution indicator of large urban areas. The multiplicity and complexity of sources of atmospheric dusts in urban regions (e.g. industrial complexes composed of a variety of industrial processes, automobiles, construction activities etc.) has put forward the need of source apportionment of these sources indi...

Worldwide drug withdrawal puts FDA under scrutiny Merck faces 300 lawsuits Karen

Vioxx is a cyclooxygenase (COX)-2 selective, non-steroidal anti-inflammatory drug (NSAID) that was approved by the USA’s Food and Drug Administration (FDA) in May 1999 for the relief of the signs and symptoms of osteoarthritis, the management of acute pain in adults, and the treatment of menstrual symptoms. Vioxx was later also approved for the relief of signs and symptoms of rheumatoid arthrit...

Regulatory paternalism in the market for drugs: lessons from Vioxx and Celebrex.

Cardiac Toxicity: Issue for Drug Safety; Goal for Prediction

blockbuster COX-2 inhibitor Vioxx (rofecoxib) as a result of an increased risk of heart attack in Vioxx users underscores the prominent role that cardiac toxicity continues to play in ensuring drug safety within the pharmaceutical industry. While the precise mechanism of Vioxx-induced cardiotoxicity is unclear, cardiac liabilities have surfaced recently for a surprising number of approved drugs...